Mechanisms of host type I interferon response modulation by the nucleocapsid proteins of alpha- and betacoronaviruses알파 및 베타 코로나바이러스의 뉴클레오캡시드 단백질에 의한 숙주 유형 I 인터페론 반응 조절 메커니즘Review Published on 2022-10-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha animals Antiviral antiviral responses betacoronavirus cause coronavirus Coronavirus infections COVID-19 pandemic Critical diarrhea epidemic diarrhea facilitate Fatality rate function genomic RNA Health Host Human humans initial innate immune response involved knowledge modulate modulation Neonatal nucleocapsid protein Nucleocapsid proteins PEDV Replication responses responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown Signaling type I interferon viral genomic RNA Viral RNA virions virus Virus-host interactions [DOI] 10.1007/s00705-022-05513-8 PMC 바로가기 [Article Type] Review
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA exportArticle Published on 2022-08-252022-11-15 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, 치료제, [키워드] accessory proteins affected Antiviral antiviral responses Betacoronavirus blocked caused Cell cellular COVID-19 disrupt ENCODE etiological agent expression Factor Health host cell identify in vitro Infectious disease inhibit inhibiting innate immune interact Interaction IRF1 mechanism modulating Molecular biology mRNA mRNA export ORF6 predicted Protein Replication RIG-I SARS-CoV-2 SARS-COV-2 infection supress utilised viral replication virus [DOI] 10.1371/journal.ppat.1010349 PMC 바로가기
Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patientsArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA microRNA. Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19 [DOI] 10.3389/fimmu.2022.968991 PMC 바로가기
Plasmacytoid dendritic cells during COVID-19: Ally or adversary?COVID-19 동안 형질세포양 수지상 세포: 동맹 또는 적Review Published on 2022-07-262022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airways Alpha Antiviral antiviral responses antivirals causative agent Cell cellular contribute coronavirus COVID-19 COVID-19 disease CP: Immunology CP: Microbiology dendritic cell dendritic cells detrimental effect detrimental effects disease IFN IFNs IFNα immune system immunology infections Inflammation Interferon alpha Microbiology outcome pDC pDCs plasmacytoid dendritic cells plasmacytoid dendritic cells. SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus subset sustained thought type I interferon viral infection viral infections virus [DOI] 10.1016/j.celrep.2022.111148 PMC 바로가기 [Article Type] Review
Construction and characterization of two SARS-CoV-2 minigenome replicon systems2개의 SARS-CoV-2 미니게놈 복제 시스템의 구성 및 특성화Article Published on 2022-06-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antiviral Antiviral agents antiviral responses Antiviral treatment biosafety biosafety level cell line cell lines cellular cellular effect characterization complementary Complementary DNA construction coronavirus COVID-19 pandemic demonstrated disease disease control DNA early phase exhibited facilitate generate global public health Host immune immune responses Impact in vitro transcription inhibitors initial Innate immunity level 2 Messenger RNA mRNA mRNA transfection mRNA/splicing nLuc phenotype portion promise Replication reporter Research SARS Coronavirus SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus Support Transcription transfection transient transfection variety Virology virus virus classification virus classification. [DOI] 10.1002/jmv.27650 PMC 바로가기 [Article Type] Article
Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells인터페론 유능한 포유동물 세포에서 항바이러스 보호를 자극하기 위한 긴 dsRNA 매개 RNA 간섭의 발견 및 사용Article Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Antiviral Antiviral effect antiviral response antiviral responses cell line cells cellular cleaved comparable competent complementary Concentration cornerstone CoV dependent on Dicer dsRNA Evidence explanation expressing fluorescent functional gene targeting generate green fluorescent protein HCoV HCoV-229E human coronavirus human coronaviruses IFN immune defense induce inducer inhibit Interference interferons knockdown Lineage Long long dsRNA mammalian mammalian cell mammalian cells Mediated mRNA pathway platform preventing infection produced protection Protein provide required responsible retained RISC RNA RNA interference RNA-induced silencing complex RNAi RNAi pathway SARS-CoV-2 replication sequence shown significantly siRNA siRNAs stimulate stomatitis suppress therapeutic These cells threshold type I interferon vesicular stomatitis vesicular stomatitis virus viral inhibition. virus VSV-GFP [DOI] 10.3389/fimmu.2022.859749 PMC 바로가기 [Article Type] Article
Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19단일 세포 전사체는 노화와 함께 축적되고 COVID-19의 질병 중증도와 상관관계가 있는 고유한 기억 유사 NK 세포 하위 집합을 나타냅니다.Article Published on 2022-05-032022-09-11 Journal: Genome Medicine [Category] Coronavirus, 유전자 메커니즘, 치료제, [키워드] accumulate accumulated age Ageing analysed analysis antiviral responses applied CD52 Cell Characteristics COVID-19 COVID-19 disease COVID-19 patient dataset disease severity distribution dysfunction exhibited exhibiting flow cytometry function healthy control healthy donor healthy donors identify IFN-α immune system immunotherapies Immunotherapy Impact in vitro individual Infectious disease Infectious diseases influence innate lymphoid cell Innate lymphoid cells interferon lymphocyte Lymphocytes natural NK cell NK cells Peripheral blood peripheral blood samples phenotype positively correlated proinflammatory proportion scRNA-seq Sequencing Seurat single-cell single-cell level single-cell RNA-seq single-cell transcriptome single-cell transcriptomes Single-cell transcriptomics subpopulation subset Transcriptome type I interferon Type-I interferon. unique [DOI] 10.1186/s13073-022-01049-3 PMC 바로가기 [Article Type] Article
Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection인간화 마우스는 SARS-CoV-2 감염 동안 인간 폐 조직 보호를 정의하는 대식세포가 풍부한 유전자 서명을 나타냅니다Article Published on 2022-04-192022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Antiviral antiviral responses cellular and molecular Clinical outcome composed COVID-19 CP: Immunology CP: Microbiology differentiation driven by fetal gene signature highlight histopathological Histopathology Human human immune response human immune responses to SARS-CoV-2 Human immune system human lung human lung tissue humanized humanized mice identify immune mechanism immune responses immunological mechanism immunology Infection knowledge lack lung Lung protection lung tissue Macrophage Macrophage infiltration Macrophage response macrophage responses macrophage responses to SARS-CoV-2 mice Microbiology mouse model Mouse models mouse models of SARS-CoV-2 pathway Phenotypes platform pulmonary immune responses. SARS-COV-2 infection severe inflammation signaling pathway tissue type I interferon upregulation [DOI] 10.1016/j.celrep.2022.110714 PMC 바로가기 [Article Type] Article
Modulation of Macrophage Polarization by Viruses: Turning Off/On Host Antiviral ResponsesMicrobiology Published on 2022-02-112022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acquisition activated macrophages Anti-inflammatory antigen-presenting cell Antiviral antiviral response antiviral responses antivirals classical Critical Defense expected facilitate hosts immune evasion impairing inhibiting invading pathogens Macrophage macrophage phenotype macrophage polarization macrophages mechanism mechanisms phenotype polarization proinflammatory Regulation regulation network Regulatory Replication response therapeutic target Turning viral infections virus [DOI] 10.3389/fmicb.2022.839585 PMC 바로가기 [Article Type] Microbiology
Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection차등 인터페론-α 아형 유도 면역 시그니처는 SARS-CoV-2 감염 억제와 관련이 있습니다420 Published on 2022-02-072022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundance activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 additive effects Analysis analysis analyzed Antiviral antiviral activity antiviral drug antiviral host response antiviral host responses antiviral response antiviral responses autoantibody Cell culture cellular Clinical treatment coronavirus Course defined disease downstream early administration Effect effector effector molecule epithelial cell epithelial cells Express functional hAEC help Host Human identify IFN-alpha IFN-I IFN-I signaling IFNs IFNα immune immune response immune responses immune signature Immune-mediated Immunity Immunotherapy Inborn error Inborn errors interferon Interferon-α interferons involved knowledge life-threatening negative regulation Pathologies Pathways pleiotropic primary human airway Primary human airway epithelial cells Prophylaxis Protective proteomic Remdesivir respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–infected mice severe acute respiratory syndrome Coronavirus signaling cascade Significance subtype Subtypes Support therapeutic approach therapeutic potential transcriptional transcriptomic analysis Treatment Type type I IFNs type I interferons Viral Viral diseases viral infections virus viruses [DOI] 10.1073/pnas.2111600119 PMC 바로가기 [Article Type] 420